Cystic Fibrosis and Male Infertility
Read now Best online medical advice on Cystic Fibrosis (CF), Vas Deferens and infertility reasons for male also treatment for infertility in males. Many people are searching for how common is infertility in males and best infertility treatment.
What is Cystic Fibrosis?
Cystic Fibrosis or CF is a progressive genetic disease of lungs and can also affect kidneys, intestine, pancreas, and liver. Patients experience the symptoms like uneasy breathing, recurring sinus infections, stunted growth and clubbing of fingers & toes.
What causes infertility in men
Almost 98% of males suffering from this disease are infertile, but not sterile, due to the absence or improperly developed Vas Deferens. There are a lot of male infertility factors are exists.
What is Vas Deferens?
It is a tubular organ that functions as a transport system for sperms in testes to reach at the back of prostate gland where it mixes with the seminal fluid (secreted by seminal vesicles) to constitute Semen. The semen can be ejaculated during the intercourse to fertilize the female egg leading to pregnancy. Read now about can male infertility be cured?
Infertility Causes – Can infertility be treated
Males suffering from CF lead a healthy sexual life however due to the absence of sperms in the semen, this disease results in male infertility known as obstructive azoospermia.
It is associated with the mutation in ‘Cystic Fibrosis Transmembrane conductance Regulator gene (CFTR).’
Such males with a CF or suffering from obstructive azoospermia due to CF mutation can experience parenthood with the available assisted reproductive technologies known as IVF.
Assisted Reproduction for Infertile Males – Best infertility treatment
Men with CF do produce sperms, but due to the dysfunctional transport system, they get accumulated in the epididymis; a duct facilitating the passage of sperms from testes to vas deferens.
Sperms retrieved directly from epididymis and eggs extracted from his female partner are allowed to fertilize in-vitro (outside the body).
Treatment for infertility in males
However, due to the lower motility of sperms in CF-affected males and abnormal fructose content & acidity in the ejaculated sperm-less semen, specialized IVF technique known as ICSI (intracytoplasmic sperm injection) is used. It is useful in 50% cases with a success rate of 40-50%.
IntraCytoplasmic Sperm Injection technique
1 Ovary stimulation using FSH hormone to produce 10 to 12 eggs (superovulation) to increase the ICSI success rate.
2 After sedation, Ultrasound-guided collection of eggs that are kept in chemically and nutritionally balanced fluid. This process takes about thirty-five minutes.
3 Under local anesthetic, sperms retrieval by direct aspiration of epididymis using a fine needle. It is known as testicular sperm aspiration (TESA) or per-cutaneous epidydimal sperm aspiration (PESA).
Alternatively, sperms can be visually extracted after an incision in the scrotum, (MESA).
1 Sperm sample preparation, examination, and selection.
2 Sperm injection into the egg body using fine pipettes.
3 Transferring of 2-4 celled embryo into the uterus after 2-3 days of fertilization.
This article is need to add more informative content about infertility surgery, male infertility clinic treatments, infertility treatment cost and male infertility factors etc.